Proteinuria typing: how, why and for whom?

被引：4

作者：

Pallet, Nicolas ^{[1
]}

Bastard, Jean-Philippe ^{[2
]}

Claeyssens, Sophie ^{[3
]}

Fellahi, Soraya ^{[2
]}

Delanaye, Pierre ^{[4
]}

Pieroni, Laurence ^{[5
]}

Causse, Elizabeth ^{[6
]}

机构：

[1] Hop Europeen Georges Pompidou, AP HP, Serv Biochim, Paris, France

[2] Hop Tenon, AP HP, UF Biomarqueurs Inflammatoires & Metabol, Serv Biochim & Hormonol, Paris, France

[3] CHU Rouen, Hop Charles Nicolle, Lab Biochim Gen, Rouen, France

[4] CHU Sart Tilman, Serv Nephrol, Dialyse, Transplantat, Liege, Belgium

[5] CHU Montpellier, Hop Lapeyronie, Dept Biochim Hormonol, Montpellier, France

[6] CHU Purpan, Lab Biochim, Inst Federatif Biol, Toulouse, France

来源：

ANNALES DE BIOLOGIE CLINIQUE | 2019年 / 77卷 / 01期

关键词：

proteinuria; urinary electrophoresis; urinary protein profiling; kidney disease; monoclonal gammopathy; ACUTE KIDNEY INJURY; PROXIMAL TUBULE; URINARY PROTEINS; MANAGEMENT; DIAGNOSIS; ELECTROPHORESIS; RECOMMENDATIONS; SERUM; IGG;

D O I：

10.1684/abc.2018.1401

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The typing of proteinuria is one of the complementary examinations carried out during the exploration of proteinuria. It aims to separate and identify the different proteins, or fractions of proteins, that make up proteinuria. The nature and relative importance of the proteins present reflect the location of the renal involvement and help to determine the etiology. The typing of a proteinuria also allows the detection of a monoclonal component in urine and its quantification. Finally, it allows highlighting the existence of a proteinuria of overload that can occur in the absence of kidney damage. Many methods allow the typing of proteinuria, and these have benefited in recent years from technological advances. The purpose of this review is to summarize typing methods currently used, their benefits and limitations, and the help that these diagnostic tools can provide to the management of patients.

引用

页码：13 / 25

页数：13

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