Synthesis of tritium labeled KRN7000

被引：13
|
作者：
Risseeuw, Martijn D. P. [1 ]
Berkers, Celia R. [1 ]
Ploegh, Hidde L. [1 ]
Ovaa, Huib [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 22期
基金：
美国国家卫生研究院;
关键词：
glycolipids; ceramides; CD1; ligands; tritiated compounds;
D O I：
10.1016/j.tetlet.2006.03.131
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of a multiple tritiated analog of KRN7000 (alpha-galactosyl ceramide) is described, enabling further studies to quantitate the affinity of KRN7000 for its receptor and to study its pharmacokinetic properties. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3677 / 3679
页数：3
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