mar Operon involved in multidrug resistance of Enterobacter aerogenes

被引：43
|
作者：
Chollet, R
Bollet, C
Chevalier, J
Malléa, M
Pagès, JM
Davin-Regli, A
机构：
[1] Univ Mediterranee, EA 2197, CJF 9606,Fac Med, Enveloppe Bacterienne Antibiot & Colonisat, F-13385 Marseille 05, France
[2] Univ Mediterranee, EA 2197, CJF 9606,Fac Pharm, Enveloppe Bacterienne Antibiot & Colonisat, F-13385 Marseille 05, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 04期
关键词：
D O I：
10.1128/AAC.46.4.1093-1097.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We determined the sequence of the entire marRAB operon in Enterobacter aerogenes. It is functionally and structurally analogous to the Escherichia coli operon. The overexpression of E. aerogenes MarA induces a multidrug resistance phenotype in a susceptible strain, demonstrated by a noticeable resistance to various antibiotics, a decrease in immunodetected porins, and active efflux of norfloxacin.
引用
收藏
页码：1093 / 1097
页数：5
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