IL-1 and anti-inflammatory drugs modulate A beta cytotoxicity in PC12 cells

被引：40
|
作者：
Fagarasan, MO [1 ]
Aisen, PS [1 ]
机构：
[1] MT SINAI MED CTR,DEPT PSYCHIAT,NEW YORK,NY 10029
来源：
BRAIN RESEARCH | 1996年 / 723卷 / 1-2期
关键词：
Alzheimer's disease; beta-amyloid; interleukin-1; inflammation; indomethacin; dexamethasone; chloroquine;
D O I：
10.1016/0006-8993(96)00259-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We studied the effect of the inflammatory cytokine interleukin-1 beta (IL-1) and several anti-inflammatory drugs on amyloid beta-peptide (A beta) cytotoxicity. Incubation of PC12 cells with 10(-6) M A beta(1-42) for 24 h reduced viabilty to 36%; coincubation with 10(-7) M IL-1 further reduced viability to 13% of baseline. With preincubation of PC12 cells with the drugs indomethacin, dexamethasone and chloroquine, reduction in viabilty was limited to 51%, 48% and 44%, respectively, compared to 32% with A beta alone. These experiments support further study of anti-inflammatory therapy in Alzheimer's disease.
引用
收藏
页码：231 / 234
页数：4
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