Highly efficient one-pot synthesis of tetrahydropyridines

被引：14

作者：

Ramin, Ghorbani-Vaghei ^{[1
]}

Hajar, Shahbazi ^{[1
]}

机构：

[1] Bu Ali Sina Univ, Fac Chem, Dept Organ Chem, Hamadan 65174, Iran

来源：

COMPTES RENDUS CHIMIE | 2013年 / 16卷 / 11期

关键词：

Multicomponent reaction; One-pot; TBBDA; PBBS; Tetrahydropyridines; Heterocycles; MULTICOMPONENT REACTION; CATALYTIC REAGENTS; N,N,N',N'-TETRABROMOBENZENE-1,3-DISULFONAMIDE; ALDEHYDES; SCAFFOLDS; ALCOHOLS; POLY(N,N'-DIBROMO-N-ETHYL-BENZENE-1,3-DISULFONAMIDE); N,N,N',N'-TETRACHLOROBENZENE-1,3-DISULFONAMIDE; DERIVATIVES; PIPERIDINES;

D O I：

10.1016/j.crci.2013.02.015

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The combination of aromatic aldehydes, and 1,3-dicarbonyl compounds in the presence of a catalytic amount of poly(N,N'-dibromo-N-ethyl-benzene-1,3-disulfonamide) [PBBS] and N,N,N',N'-tetrabromobenzene-1,3-disulfonamide [TBBDA] leads to the formation of highly substituted tetrahydropyridines. In this way, a series of pharmacologically interesting substituted piperidine derivatives were obtained in moderate to high yields at room temperature. (C) 2013 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：1047 / 1054

页数：8

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