Investigation into the correlation between efficacy and KL:KH affinity ratio for the dopamine D2S receptor

被引:0
|
作者
Spragg, EJ [1 ]
Charlton, SJ [1 ]
Scaramellini, CM [1 ]
机构
[1] Novartis Horsham Res Ctr, Horsham RH12 5AB, W Sussex, England
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
340P
引用
收藏
页数:1
相关论文
共 50 条
  • [31] RELATIVE DOPAMINE D1 AND D2 RECEPTOR AFFINITY AND EFFICACY DETERMINE WHETHER DOPAMINE AGONISTS INDUCE HYPERACTIVITY OR ORAL STEREOTYPY IN RATS
    ARNT, J
    BOGESO, KP
    HYTTEL, J
    MEIER, E
    PHARMACOLOGY & TOXICOLOGY, 1988, 62 (03): : 121 - 130
  • [32] Preferential Coupling of Dopamine D2S and D2L Receptor Isoforms with Gi1 and Gi2 Proteins-In Silico Study
    Zuk, Justyna
    Bartuzi, Damian
    Matosiuk, Dariusz
    Kaczor, Agnieszka A.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (02)
  • [33] Aripiprazole's low intrinsic activities at human dopamine D2L and D2S receptors render it a unique antipsychotic
    Tadori, Y
    Miwa, T
    Tottori, K
    Burris, KD
    Stark, A
    Mori, T
    Kikuchi, T
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2005, 515 (1-3) : 10 - 19
  • [34] Differential contribution of dopamine D2S and D2L receptors in the modulation of glutamate and GABA transmission in the striatum
    Centonze, D
    Gubellini, P
    Usiello, A
    Rossi, S
    Tscherter, A
    Bracci, E
    Erbs, E
    Tognazzi, N
    Bernardi, G
    Pisani, A
    Calabresi, P
    Borrelli, E
    NEUROSCIENCE, 2004, 129 (01) : 157 - 166
  • [35] CORRESPONDENCY BETWEEN DIFFERENT AFFINITY STATES AND TARGET SIZE OF THE BOVINE STRIATAL D2-DOPAMINE RECEPTOR
    KUNO, T
    TANAKA, C
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 117 (01) : 65 - 70
  • [36] The effect of ionic environments on' the affinity of D2-dopamine receptor radioligands
    Parker, CA
    Matthews, JC
    Brown, J
    Gee, AD
    Rabiner, EA
    JOURNAL OF PSYCHOPHARMACOLOGY, 2005, 19 (05) : A53 - A53
  • [37] Production of the human D2S receptor in the methylotrophic yeast P-pastoris
    Grünewald, S
    Haase, W
    Molsberger, E
    Michel, H
    Reiländer, H
    RECEPTORS & CHANNELS, 2004, 10 (01): : 37 - 50
  • [38] G protein specificity of dopamine D2S receptor signalling in Ltk- cells: Use of pertussis toxin G protein mutants
    Ghahremani, MH
    Lembo, P
    Albert, PR
    JOURNAL OF NEUROCHEMISTRY, 1997, 69 : S28 - S28
  • [39] Dopamine D2S and D2L receptors may differentially contribute to the actions of antipsychotic and psychotic agents in mice
    Xu, R
    Hranilovic, D
    Fetsko, LA
    Bucan, M
    Wang, Y
    MOLECULAR PSYCHIATRY, 2002, 7 (10) : 1075 - 1082
  • [40] Dopamine D2S and D2L receptors may differentially contribute to the actions of antipsychotic and psychotic agents in mice
    R Xu
    D Hranilovic
    L A Fetsko
    M Bucan
    Y Wang
    Molecular Psychiatry, 2002, 7 : 1075 - 1082