Inhibitory effects of hypertonic saline on P. aeruginosa motility

被引：20
|
作者：
Havasi, Viktoria [1 ]
Hurst, Casey O. [1 ]
Briles, Travis C. [1 ]
Yang, Fan [1 ]
Bains, David G. [1 ]
Hassett, Daniel J. [2 ]
Sorscher, Eric [1 ]
机构：
[1] Univ Alabama, Gregory Fleming James Cyst Fibrosis Res Ctr, Birmingham, AL 35294 USA
[2] Univ Cincinnati, Coll Med, Dept Mol Genet Biochem & Microbiol, Cincinnati, OH 45267 USA
来源：
JOURNAL OF CYSTIC FIBROSIS | 2008年 / 7卷 / 04期
关键词：
mucociliary clearance; cystic fibrosis; high salt;
D O I：
10.1016/j.jcf.2007.11.009
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Salt transport defects in CF lungs predispose to overwhelming and fatal respiratory infection caused by Pseudomonas aeruginosa. Motility of this organism is central to pathogenesis in a number of settings. Incubation of numerous strains of P. aeruginosa with hypertonic saline caused a concentration-dependent decrease in bacterial motility. Reduction of P. aeruginosa virulence through this effect may contribute to clinical efficacy of hypertonic saline aerosols in CF patients. (C) 2007 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：267 / 269
页数：3
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