IDH1 Mutation in Pediatric Gliomas: Has it a Diagnostic and Prognostic Value?

被引：11

作者：

Buccoliero, Anna Maria ^{[1
]}

Castiglione, Francesca ^{[2
]}

Degl'Innocenti, Duccio Rossi ^{[2
]}

Gheri, Chiara Francesca ^{[2
]}

Genitori, Lorenzo ^{[3
]}

Taddei, Gian Luigi ^{[2
]}

机构：

[1] Anna Meyer Childrens Hosp, Pathol Unit, I-50100 Florence, Italy

[2] Careggi Hosp, Dept Biomed, Florence, Italy

[3] Anna Meyer Childrens Hosp, Dept Neurosurg, Florence, Italy

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2012年 / 31卷 / 05期

关键词：

IDH1; glioma; astrocytoma; pediatric; children;

D O I：

10.3109/15513815.2012.659383

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Mutations in IDH1 gene are observed in gliomas with significant differences according to histotype, grade, prognosis, and age. We analyzed the IDH1 gene mutations frequency in 42 gliomas from 40 children (14 pilocytic astrocytomas; 3 pilomyxoid astrocytomas; 3 diffuse astrocytomas; 1 gliomatosi cerebri; 8 subependymal giant cell astrocytomas; 2 anaplastic astrocytomas; 9 glioblastomas). No IDH1 mutation was detected. Our results indicate that there is no IDH1 gene involvement in the onset and progression of pediatric astrocytomas. We argue that it is not useful in children to assess the status of IDH1 gene nor for diagnostic nor prognostic purposes.

引用

页码：278 / 282

页数：5

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