The IGF-I/IGF-IR Signaling System and Pancreatic Cancer

被引：2
|
作者：
Kopantzev, E. P. [1 ]
Grankina, E. V. [1 ]
Kopantseva, M. R. [1 ]
Sverdlov, E. D. [1 ]
机构：
[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
来源：
MOLECULAR GENETICS MICROBIOLOGY AND VIROLOGY | 2017年 / 32卷 / 03期
基金：
俄罗斯科学基金会;
关键词：
insulin-like growth factor 1; pancreas; tumor; stromal microenvironment; therapy; review; GROWTH-FACTOR RECEPTOR; INSULIN; HEDGEHOG; P53; MICROENVIRONMENT; PHOSPHORYLATION; OVEREXPRESSION; CHEMOTHERAPY; METASTASIS; EXPRESSION;
D O I：
10.3103/S0891416817030041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ductal adenocarcinoma is one of the most common and severely aggressive forms of pancreatic cancer. IGF-I is one of the factors that ensures survival and proliferation of tumor cells, and its increased concentration inside the tumor is a characteristic sign of many malignant formations. The goal of this minireview is to provide an up-to-date insight on the roles of the IGF-I/IGF-IR signaling pathway in carcinogenesis and potential opportunities for pharmacologic targeting of IGF-I/IGF-IR in pancreatic tumors.
引用
收藏
页码：131 / 136
页数：6
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