The IGF-I/IGF-IR Signaling System and Pancreatic Cancer

被引：2
|
作者：
Kopantzev, E. P. [1 ]
Grankina, E. V. [1 ]
Kopantseva, M. R. [1 ]
Sverdlov, E. D. [1 ]
机构：
[1] Russian Acad Sci, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia
来源：
MOLECULAR GENETICS MICROBIOLOGY AND VIROLOGY | 2017年 / 32卷 / 03期
基金：
俄罗斯科学基金会;
关键词：
insulin-like growth factor 1; pancreas; tumor; stromal microenvironment; therapy; review; GROWTH-FACTOR RECEPTOR; INSULIN; HEDGEHOG; P53; MICROENVIRONMENT; PHOSPHORYLATION; OVEREXPRESSION; CHEMOTHERAPY; METASTASIS; EXPRESSION;
D O I：
10.3103/S0891416817030041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ductal adenocarcinoma is one of the most common and severely aggressive forms of pancreatic cancer. IGF-I is one of the factors that ensures survival and proliferation of tumor cells, and its increased concentration inside the tumor is a characteristic sign of many malignant formations. The goal of this minireview is to provide an up-to-date insight on the roles of the IGF-I/IGF-IR signaling pathway in carcinogenesis and potential opportunities for pharmacologic targeting of IGF-I/IGF-IR in pancreatic tumors.
引用
收藏
页码：131 / 136
页数：6
相关论文
共 50 条
  • [1] The IGF-I/IGF-IR Signaling System and Pancreatic Cancer
    E. P. Kopantzev
    E. V. Grankina
    M. R. Kopantseva
    E. D. Sverdlov
    Molecular Genetics, Microbiology and Virology, 2017, 32 : 131 - 136
  • [2] Localization of IGF-I and IGF-IR in Equine Testes.
    Yoon, Minjung
    Roser, Janet F.
    BIOLOGY OF REPRODUCTION, 2009, : 201 - 201
  • [3] Inhibition of colon cancer cell growth via IGF-I antagonism: Antibody to IGF-IR, IGF-IR antisense and IGFBP-3
    Kirman, T
    Poltoratskaia, N
    Whelan, RL
    GASTROENTEROLOGY, 2003, 124 (04) : A34 - A34
  • [4] Decorin Antagonizes IGF Receptor I (IGF-IR) Function by Interfering with IGF-IR Activity and Attenuating Downstream Signaling
    Iozzo, Renato V.
    Buraschi, Simone
    Genua, Marco
    Xu, Shi-Qiong
    Solomides, Charalambos C.
    Peiper, Stephen C.
    Gomella, Leonard G.
    Owens, Rick C.
    Morrione, Andrea
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (40) : 34712 - 34721
  • [5] Sequence-specific targeting of IGF-I and IGF-IR genes by camptothecins
    Oussedik, Kahina
    Francois, Jean-Christophe
    Halby, Ludovic
    Senamaud-Beaufort, Catherine
    Toutirais, Geraldine
    Dallavalle, Sabrina
    Pommier, Yves
    Pisano, Claudio
    Arimondo, Paola B.
    FASEB JOURNAL, 2010, 24 (07): : 2235 - 2244
  • [6] The Effect of Capsaicin on IGF-I and IGF-IR Expression in Ovarian Granulosa Cells
    Guler, S.
    Zik, B.
    JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY, 2020, 71 (01): : 1977 - 1984
  • [7] IGF-I receptor (IGF-IR) function in prolonged acute uremia.
    Tsao, T
    Friedlaender, MM
    Hsu, FW
    Fervenza, F
    Rabkin, R
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1997, 8 : A2942 - A2942
  • [8] Localization of Insulin-Like Growth Factor-I (IGF-I) and IGF-I Receptor (IGF-IR) in Equine Testes
    Yoon, M. J.
    Berger, T.
    Roser, J. F.
    REPRODUCTION IN DOMESTIC ANIMALS, 2011, 46 (02) : 221 - 228
  • [9] Rapid induction of IGF-IR signaling in normal and tumor tissue following intravenous injection of IGF-I in mice
    Lee, AV
    Taylor, ST
    Greenall, J
    Mills, JD
    Tonge, DW
    Zhang, P
    George, J
    Fiorotto, ML
    Hadsell, DL
    HORMONE AND METABOLIC RESEARCH, 2003, 35 (11-12) : 651 - 655
  • [10] Interaction between IGF-IR and ER Induced by E2 and IGF-I
    Yu, Zhenghong
    Gao, Weimin
    Jiang, Enze
    Lu, Fang
    Zhang, Luo
    Shi, Zhaorong
    Wang, Xinxing
    Chen, Longbang
    Lv, Tangfeng
    PLOS ONE, 2013, 8 (05):
12345