Electrochemical and spectroscopic investigations of carboxylic acid ligand and its triorganotin complexes for their binding with ds.DNA: In vitro biological studies

被引：37
|
作者：
Arshad, Nasima [1 ]
Farooqi, Shahid Iqbal [1 ]
Bhatti, Moazzam H. [1 ]
Saleem, Samreen [2 ]
Mirza, Bushra [2 ]
机构：
[1] Allama Iqbal Open Univ, Dept Chem, Islamabad, Pakistan
[2] Quaid I Azam Univ, Dept Biochem, Islamabad, Pakistan
来源：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 2013年 / 125卷
关键词：
Triorganotin(IV) carboxylates; UV-visible/fluorescence spectroscopy; Cyclic voltammerty; Intercalation; Binding constant/site size; Bioactivities; TRANSFER FLUORESCENCE PROBE; DNA-BINDING; ANTITUMOR ACTIVITIES; ORGANOTIN COMPOUNDS; CRYSTAL-STRUCTURE; METAL-COMPLEXES; SERUM-ALBUMIN; DERIVATIVES; DRUG; DIORGANOTIN(IV);
D O I：
10.1016/j.jphotobiol.2013.05.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A carboxylic acid ligand, (Z)-4-(4-acelylphenylamino)-4-oxobut-2-enoic acid (APA-1), and its triphenyl(APA-2) and tributyl-tin(IV) (APA-3) compounds have been synthesized and investigated for their binding with ds.DNA using UV-visible spectroscopy, fluorescence spectroscopy, cyclic voltammetry, and viscosity measurements under physiological conditions of pH and temperature. The experimental results from all techniques i.e. binding constant (K-b), binding site size (n) and free energy change (Delta G) were in good agreement and inferred spontaneous compound-DNA complexes formation via intercalation. Among all the compounds APA-3 showed comparatively greater binding at pH 4.7 as evident from its greater K-b values {APA-3: K-b: 5.63 x 10(4) M-1 (UV); 7.94 x .10(4) M-1 (fluorescence); 9.91 x 10(4) M-1 (CV)}. Electrochemical processes of compounds before and after the addition of DNA were found diffusion controlled. Among all compounds, APA-3 exhibited best antitumor activity. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：70 / 82
页数：13
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