Graphene nano-ink biosensor arrays on a microfluidic paper for multiplexed detection of metabolites

被引:54
|
作者
Labroo, Pratima [1 ]
Cui, Yue [1 ]
机构
[1] Utah State Univ, Dept Biol Engn, Logan, UT 84322 USA
关键词
Graphene ink; Microfluidic paper; Biosensor arrays; Multiplexed; Metabolite; LAYER GRAPHENE; SENSORS; PERFORMANCE; ELECTRONICS; XANTHINE; LACTATE; DEVICES;
D O I
10.1016/j.aca.2014.01.024
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The development of a miniaturized and low-cost platform for the highly sensitive, selective and rapid detection of multiplexed metabolites is of great interest for healthcare, pharmaceuticals, food science, and environmental monitoring. Graphene is a delicate single-layer, two-dimensional network of carbon atoms with extraordinary electrical sensing capability. Microfluidic paper with printing technique is a low cost matrix. Here, we demonstrated the development of graphene-ink based biosensor arrays on a microfluidic paper for the multiplexed detection of different metabolites, such as glucose, lactate, xanthine and cholesterol. Our results show that the graphene biosensor arrays can detect multiple metabolites on a microfluidic paper sensitively, rapidly and simultaneously. The device exhibits a fast measuring time of less than 2 min, a low detection limit of 0.3 mu M, and a dynamic detection range of 0.3-15 mu M. The process is simple and inexpensive to operate and requires a low consumption of sample volume. We anticipate that these results could open exciting opportunities for a variety of applications. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:90 / 96
页数:7
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