Is N-acetyl cysteine protective against monocrotaline-induced toxicity?

被引：2
|
作者：
Karagoz, Serife [1 ]
Ilgin, Sinem [1 ]
Atli, Ozlem [1 ]
Perk, Basak Ozlem [1 ]
Burukoglu, Dilek [2 ]
Ergun, Bulent [1 ]
Sirmagul, Basar [3 ]
机构：
[1] Anadolu Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-26470 Eskisehir, Turkey
[2] Osmangazi Univ, Fac Med, Dept Histol, Eskisehir, Turkey
[3] Osmangazi Univ, Fac Med, Dept Pharmacol, Eskisehir, Turkey
来源：
TOXIN REVIEWS | 2013年 / 32卷 / 03期
关键词：
Glutathione; hepatotoxicity; monocrotaline; N-acetyl cysteine; pulmonary toxicity; INDUCED PULMONARY-HYPERTENSION; ACETAMINOPHEN-INDUCED HEPATOTOXICITY; HEPATIC VENOOCCLUSIVE DISEASE; ENDOTHELIAL-CELL INJURY; PYRROLIZIDINE ALKALOIDS; LIVER INFLAMMATION; LIPID-PEROXIDATION; OXIDATIVE DAMAGE; RAT MODEL; ACETYLCYSTEINE;
D O I：
10.3109/15569543.2013.809547
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Monocrotaline (MCT) is a pyrrolizidine alkaloid which induces cardio-pulmonary toxicity and hepatotoxicity in animals and humans. MCT is frequently ingested because of food grain contamination accidentally or in the form of herbal medicine preparations. The aim of this study was to observe the protective effect of N-acetyl cysteine (NAC) on MCT-induced pulmonary toxicity and hepatotoxicity. According to our results (right ventricular pressures [RVPs], ratios of right ventricle (RV)/heart weight (HW), plasma AST levels, liver glutathione levels, liver MDA levels and liver histopathological examinations of groups), protective effects were observed with NAC treatment in both MCT-induced pulmonary toxicity and hepatotoxicity.
引用
收藏
页码：47 / 54
页数：8
相关论文
共 50 条
  • [21] Protective effect of N-acetyl cysteine, a glutathione precursor against ICV streptozotocin-induced Alzheimer rat model
    Prakash, A.
    Majeed, A. B.
    Ramasamy, K.
    Mani, V.
    Kumar, A.
    JOURNAL OF NEUROCHEMISTRY, 2015, 134 : 276 - 277
  • [22] STATUS OF N-ACETYL CYSTEINE?
    Gold, Joanne
    Marion, Donald
    JOURNAL OF NEUROTRAUMA, 2019, 36 (13) : A78 - A79
  • [23] KRATOM INDUCED HEPATOTOXICITY AND THE ROLE OF N-ACETYL CYSTEINE
    Desai, P.
    Ramachandra, K.
    Shah, M.
    JOURNAL OF INVESTIGATIVE MEDICINE, 2019, 67 (02) : 606 - 606
  • [24] Aldehyde induced hypertension: Prevention by n-acetyl cysteine
    Vasdev, S
    Ford, CA
    Longerich, L
    Parai, S
    Gadag, V
    Wadhawan, S
    JOURNAL OF HYPERTENSION, 1998, 16 : S156 - S156
  • [25] Protecting Effects of N-acetyl Cysteine Supplementation Against Lead and Cadmium-Induced Brain Toxicity in Rat Models
    MohammadMahdi Jaafarzadeh
    Roham Mahjoob Khaligh
    Zhaleh Mohsenifar
    Aida Shabani
    MohammadMahdi Rezvani Gilkalaei
    Sara Rajabi Keleshteri
    Asghar Beigi Harchegani
    Biological Trace Element Research, 2022, 200 : 4395 - 4403
  • [26] HISTAMINE-SECRETION INDUCED BY N-ACETYL CYSTEINE
    BARRETT, KE
    MINOR, JR
    METCALFE, DD
    AGENTS AND ACTIONS, 1985, 16 (3-4): : 144 - 146
  • [27] Protecting Effects of N-acetyl Cysteine Supplementation Against Lead and Cadmium-Induced Brain Toxicity in Rat Models
    Jaafarzadeh, MohammadMahdi
    Khaligh, Roham Mahjoob
    Mohsenifar, Zhaleh
    Shabani, Aida
    Gilkalaei, MohammadMahdi Rezvani
    Keleshteri, Sara Rajabi
    Harchegani, Asghar Beigi
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2022, 200 (10) : 4395 - 4403
  • [28] Drug-Induced Liver Injury: Clinical Evidence of N-Acetyl Cysteine Protective Effects
    Ntamo Y.
    Ziqubu K.
    Chellan N.
    Nkambule B.B.
    Nyambuya T.M.
    Mazibuko-Mbeje S.E.
    Gabuza K.B.
    Marcheggiani F.
    Tiano L.
    Dludla P.V.
    Oxidative Medicine and Cellular Longevity, 2021, 2021
  • [29] Protective effects of erythropoietin and N-acetyl cysteine on methotrexate-induced lung injury in rats
    Kahraman, Hasan
    Tokur, Mahmut
    Kurutas, Ergul
    Bozkurt, Selim
    Bakan, Vedat
    Ciralik, Harun
    Koksal, Nurhan
    EUROPEAN RESPIRATORY JOURNAL, 2012, 40
  • [30] N-Acetyl Cysteine Alleviates Cognitive Dysfunction and Oxidative Damage Induced By Aluminium Toxicity in Rats
    Arti
    Prakash, Atish
    Kumar, Anil
    INDIAN JOURNAL OF PHARMACOLOGY, 2013, 45 : S233 - S233
12345