Different pH-values of Release Medium Influence the Drug release from PTX-PCL Microspheres

被引：3
|
作者：
Ruan, Lili [1 ]
Wang, Daxin [2 ]
Zhang, Youwei [1 ]
Zhao, Jiongxin [1 ]
Zhang, Xiufang [1 ]
NanliangChen [3 ]
机构：
[1] Donghua Univ, Coll Mat Sci & Engn, Shanghai 201620, Peoples R China
[2] Yangzhou Univ, Med Acad, Yangzhou 225001, Jiangsu, Peoples R China
[3] Donghua Univ, Minist Educ, Key Lab Text Sci & Technol, Shanghai 201620, Peoples R China
来源：
ADVANCED COMPOSITE MATERIALS, PTS 1-3 | 2012年 / 482-484卷
关键词：
Different pH-values; paclitaxel; polycaprolactone; microspheres; TAXOL;
D O I：
10.4028/www.scientific.net/AMR.482-484.2605
中图分类号：
TB33 [复合材料];
学科分类号：
摘要：
In this paper we study in vitro release of paclitaxel-loade polycaprolactone sustained-release microspheres. Different pH values release medium is used to simulate pH conditions in different parts of body, and determination the paclitaxel in Microspheres by High Performance Liquid Chromatography according Chinese Pharmacopoeia 2010. The experimental results indicate that the microspheres release rates of same drug loading content in buffer solution of pH 7.35 is the fastest, and in the pH 1.2 is the slowest. The drug release behavior according to the first-order model and it is not affected by drug loading rate of microspheres. The prepared paclitaxel-loade polycaprolactone sustained-release microspheres has good sustained release effect in different release media, and the results can provide references for further study of in vivo release.
引用
收藏
页码：2605 / +
页数：2
相关论文
共 50 条
  • [11] Influence of Solution pH on Drug Release from Ionic Hydrogel Lens
    Kim, Guenhei
    Kim, Hyeok Jung
    Noh, Hyeran
    MACROMOLECULAR RESEARCH, 2019, 27 (02) : 191 - 197
  • [12] Morphology and drug release of pH-sensitive microspheres containing flavonoids
    Scarfato, Paola
    Elvira, Avallone
    Pio, Iannelli
    Rita, Aquino
    Domenico, Acierno
    IVTH INTERNATIONAL CONFERENCE ON TIMES OF POLYMERS (TOP) AND COMPOSITES, 2008, 1042 : 99 - +
  • [13] ULTRASOUND-TRIGGERED DRUG RELEASE FROM HYDROGEL MICROSPHERES WITH RELEASE BOOSTER
    Kubota, Takeshi
    Kurashina, Yuta
    Onoe, Hiroaki
    2021 34TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2021), 2021, : 26 - 28
  • [14] Effect of drug stability on the analysis of release data from controlled release microspheres
    Kim, H
    Burgess, DJ
    JOURNAL OF MICROENCAPSULATION, 2002, 19 (05) : 631 - 640
  • [15] Influence of glutaraldehyde on drug release and mucoadhesive properties of chitosan microspheres
    Genta, I
    Costantini, M
    Asti, A
    Conti, B
    Montanari, L
    CARBOHYDRATE POLYMERS, 1998, 36 (2-3) : 81 - 88
  • [16] Microcosmic Mechanism of the Particle Release under Different pH Values
    Han Zhiyong
    Feng Xin
    Xie Gang
    PROGRESS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY, VOL III: PROCEEDINGS OF THE 2011 INTERNATIONAL SYMPOSIUM ON ENVIRONMENTAL SCIENCE AND TECHNOLOGY, 2011, : 198 - 204
  • [17] Understanding drug release from PCL/gelatin electrospun blends
    Munj, Hrishikesh R.
    Lannutti, John J.
    Tomasko, David L.
    JOURNAL OF BIOMATERIALS APPLICATIONS, 2017, 31 (06) : 933 - 949
  • [18] Pesticide and model drug release from carboxymethylceullose microspheres
    Darvari, R
    Hasirci, V
    JOURNAL OF MICROENCAPSULATION, 1996, 13 (01) : 9 - 24
  • [19] Hydrophilic drug release from bioerodible polyanhydride microspheres
    Vasheghani-Farahani, E
    Khorram, M
    JOURNAL OF APPLIED POLYMER SCIENCE, 2002, 83 (07) : 1457 - 1464
  • [20] Effects of Dissolution Medium pH and Simulated Gastrointestinal Contraction on Drug Release From Nifedipine Extended-Release Tablets
    Gao, Zongming
    Ngo, Cindy
    Ye, Wei
    Rodriguez, Jason D.
    Keire, David
    Sun, Dajun
    Wen, Hong
    Jiang, Wenlei
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 108 (03) : 1189 - 1194
12345