Different pH-values of Release Medium Influence the Drug release from PTX-PCL Microspheres

被引：3
|
作者：
Ruan, Lili [1 ]
Wang, Daxin [2 ]
Zhang, Youwei [1 ]
Zhao, Jiongxin [1 ]
Zhang, Xiufang [1 ]
NanliangChen [3 ]
机构：
[1] Donghua Univ, Coll Mat Sci & Engn, Shanghai 201620, Peoples R China
[2] Yangzhou Univ, Med Acad, Yangzhou 225001, Jiangsu, Peoples R China
[3] Donghua Univ, Minist Educ, Key Lab Text Sci & Technol, Shanghai 201620, Peoples R China
来源：
ADVANCED COMPOSITE MATERIALS, PTS 1-3 | 2012年 / 482-484卷
关键词：
Different pH-values; paclitaxel; polycaprolactone; microspheres; TAXOL;
D O I：
10.4028/www.scientific.net/AMR.482-484.2605
中图分类号：
TB33 [复合材料];
学科分类号：
摘要：
In this paper we study in vitro release of paclitaxel-loade polycaprolactone sustained-release microspheres. Different pH values release medium is used to simulate pH conditions in different parts of body, and determination the paclitaxel in Microspheres by High Performance Liquid Chromatography according Chinese Pharmacopoeia 2010. The experimental results indicate that the microspheres release rates of same drug loading content in buffer solution of pH 7.35 is the fastest, and in the pH 1.2 is the slowest. The drug release behavior according to the first-order model and it is not affected by drug loading rate of microspheres. The prepared paclitaxel-loade polycaprolactone sustained-release microspheres has good sustained release effect in different release media, and the results can provide references for further study of in vivo release.
引用
收藏
页码：2605 / +
页数：2
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