A study on the sealing ability and antibacterial activity of Ca3SiO5/CaCl2 composite cement for dental applications

The objective of this study was to evaluate the sealing ability and antibacterial activity of Ca3SiO5/CaCl2 composite cement. Fifty maxillary anterior teeth were instrumented according to step-back technique and filled with experimental and control materials. To evaluate the sealing ability, a fluid transport model using glucose was employed for quantitative analysis of endodontic microleakage. To evaluate antibacterial activity, E. colias (ATCC 25922) was cultivated on agar plates. Results showed that the sealing ability of Ca3SiO5/CaCl2 composite cement and cortisomol paste were higher than that of zinc oxide-eugenol (ZOE) cement, and that no significant difference was observed between Ca3SiO5/CaCl2 composite cement and cortisomol paste. On antibacterial activity, Ca3SiO5/CaCl2 composite cements composed of varying amounts of CaCl2 (0-15%) exhibited similar levels of activity against E. colias as calcium hydroxide cement, whereas cortisomol paste had little effect on E. colias. All these results suggested that Ca3SiO5/CaCl2 composite cement demonstrated good potential for root canal treatment applications.