One-pot synthesis of 1,2,4,5-tetrasubstituted imidazoles by a tandem three-component reaction of hydroxylamines, aldehydes and 2-azido acrylates

被引：9
|
作者：
Hu, Bao [1 ,2 ]
Ai, Ning [1 ]
Wang, Zhao [1 ]
Xu, Xiaoliang [1 ,2 ]
Li, Xiaonian [1 ,2 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn & Mat Sci, Hangzhou 310014, Zhejiang, Peoples R China
[2] Zhejiang Univ Technol, Inst Ind Catalysis, Hangzhou 310014, Zhejiang, Peoples R China
来源：
ARKIVOC | 2012年
关键词：
Hydroxylamines; aldehydes; 2-azido acrylates; multicomponent reactions; imidazoles; ANTITUMOR-ACTIVITY; VINYL AZIDES; PYRROLES; 2-AZIDOACRYLATES; ISOQUINOLINES; PYRIDINES; INDOLES; OXAZOLE; ANALOGS; AGENTS;
D O I：
10.3998/ark.5550190.0013.621
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The reaction of nitrones, formed in situ by reaction of hydroxylamines and aldehydes, with 2-azido acrylates results in the formation of 1,2,4,5-tetrasubstituted imidazoles has been developed. This three-component reaction allows for the formation of a diverse array of imidazole derivatives with moderate to excellent yields.
引用
收藏
页码：222 / 228
页数：7
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