Chitooligosaccharides induce apoptosis in human myeloid leukemia HL-60 cells

被引：37

作者：

Kim, Eun-Kyung ^{[2
,4
]}

Je, Jae-Young ^{[3
]}

Lee, Seung-Jae ^{[1
]}

Kim, Yon-Suk ^{[1
]}

Hwang, Jin-Woo ^{[1
]}

Sung, Si-Heung ^{[2
]}

Moon, Sang-Ho ^{[4
]}

Jeon, Byong-Tae ^{[4
]}

Kim, Se-Kwon ^{[5
]}

Jeon, You-Jin ^{[6
]}

Park, Pyo-Jam ^{[1
,4
]}

机构：

[1] Konkuk Univ, Dept Biotechnol, Chungju 380701, South Korea

[2] Konkuk Univ, Dept Food Life Sci, Chungju 380701, South Korea

[3] Chonnam Natl Univ, Dept Food Technol & Nutr, Yeosu 350749, South Korea

[4] Konkuk Univ, Korean Nokyong Res Ctr, Chungju 380701, South Korea

[5] Pukyong Natl Univ, Dept Chem, Pusan 608737, South Korea

[6] Jeju Natl Univ, Fac Appl Marine Sci, Cheju 690756, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 19期

关键词：

Hetero-chitooligosaccharide; Deacetylation; Molecular weight; Anticancer; HETERO-CHITOOLIGOSACCHARIDES; ANTIMICROBIAL ACTIVITY; CHITOSAN; CANCER; PREVENTION; WEIGHT;

D O I：

10.1016/j.bmcl.2012.08.030

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this study we propose a novel anticancer agent using hetero-chitooligosaccharide (hetero-COS). To examine the possibility of the hetero-COS as a anticancer agent, we prepared nine kinds of hetero-COS with relatively higher molecular weights (90, 75 and 50-COS I, 5 similar to 10 kDa), medium molecular weights (90, 75 and 50-COS II, 1 similar to 5 kDa), and lower molecular weights (90, 75 and 50-III, below 1 kDa), and their anticancer properties were investigated on HL-60 cells using flow cytometry and morphological analysis. The results obtained indicate that 90-COS III, which is relatively higher degree of deacetylation and lower molecular weights, showed the highest anticancer activity, and the data showed the anticancer property of the hetero-COSs depended on their degree of deacetylation values and molecular weight. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：6136 / 6138

页数：3

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