Overexpression of Rho-GDP-Dissociation Inhibitor-γ Inhibits Migration of Neural Stem Cells

被引：6

作者：

Wang, Jiao ^{[1
,2
]}

Li, Xiao ^{[1
]}

Cheng, Hua ^{[1
]}

Wang, Kai ^{[1
]}

Lu, Wei ^{[1
]}

Wen, Tieqiao ^{[1
,2
]}

机构：

[1] Shanghai Univ, Sch Life Sci, Inst Syst Biol, Lab Mol Neural Biol, Shanghai 200444, Peoples R China

[2] Shanghai Univ, Sch Commun & Informat Engn, Shanghai 200444, Peoples R China

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2013年 / 91卷 / 11期

基金：

中国国家自然科学基金;

关键词：

neural stem cell; migration; Rac1; Rho-GDI; ACTIN CYTOSKELETON; GTPASES;

D O I：

10.1002/jnr.23261

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neural stem cell (NSC) migration relies heavily on the regulation of actin and microtubule cytoskeletons by Rho GTPases, which are critical regulators of key steps during NSC migration. However, the migration mechanism remains unclear. Rho-GDP-dissociation inhibitor- (Rho-GDI) was identified as an important downregulator of the Rho family of GTPases, because of its ability to prevent nucleotide exchange and thus membrane association. This study investigates the role of Rho-GDI in neural stem cells migration. Our results indicate that the overexpression of Rho-GDI maintains NSCs in the stem cell state, meanwhile preventing NSC migration through inhibition of Rac1 expression, one of the Rho-family GTPases. This study provides the basis for further study of the molecular mechanism of NSC migration. (c) 2013 Wiley Periodicals, Inc.

引用

页码：1394 / 1401

页数：8

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