Sulfonylation of Propargyl Alcohols with Sulfinamides for the Synthesis of Allenyl Sulfones

被引：9

作者：

Zou, Fei-Fei ^{[1
]}

Luo, Zhen ^{[1
]}

Yang, Yu-Ting ^{[1
]}

Zhuang, Xin ^{[1
]}

Hong, Chuan-Ming ^{[1
]}

Liu, Zheng-Qiang ^{[1
]}

Li, Wan-Fang ^{[2
]}

Li, Qing-Hua ^{[1
]}

Liu, Tang-Lin ^{[1
]}

机构：

[1] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China

[2] Univ Shanghai Sci & Technol, Coll Sci, Shanghai 200093, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 22期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; ASYMMETRIC-SYNTHESIS; T-BUTYLSULFINAMIDE; REARRANGEMENT; LEWIS; ISOMERIZATION; BRASSINOLIDE; CHEMISTRY; EFFICIENT; SOLVENTS;

D O I：

10.1021/acs.joc.2c01495

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A regio-and chemoselective sulfonylation of propargyl alcohols with sulfinamides in 1,1,1,3,3,3-hexafluoroisopro-panol (HFIP) was developed. It provided straightforward and mild access to multi-substituted allenyl sulfones by using sulfinamides as the sulfonyl sources. This transformation was promoted by HFIP and did not require any catalysts or oxidants, which allowed for the successful conversion of various tertiary and secondary propargyl alcohols into allenyl sulfones in high yields.

引用

页码：15061 / 15070

页数：10

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