Neuroendocrine abnormalities in recreational ecstasy (MDMA) users: Is it ecstasy or cannabis?

被引：19

作者：

Gouzoulis-Mayfrank, E ^{[1
]}

Becker, S ^{[1
]}

Pelz, S ^{[1
]}

Tuchtenhagen, F ^{[1
]}

Daumann, J ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Fac Med, Dept Psychiat & Psychotherapy, D-52074 Aachen, Germany

来源：

BIOLOGICAL PSYCHIATRY | 2002年 / 51卷 / 09期

关键词：

ecstasy; MDMA; cannabis; neurotoxicity; serotonin; d-fenfluramine;

D O I：

10.1016/S0006-3223(01)01306-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: The purpose of this study was to investigate neuroendocrine function in ecstasy (3,4-methylenedioxymethamphetamine = MDMA) users and controls. Methods: Prolactin response to d-fenfluramine was assessed in abstinent ecstasy users with concomitant use of cannabis only (n = 24, male/female 13/11) and in two control groups: healthy nonusers (n = 13, female) and exclusive cannabis users (n = 7, male). Results: Prolactin response to d-fenfluramine was slightly blunted in female ecstasy users. Both male user samples exhibited a weak prolactin response to d-fenfluramine, but this was weaker in the group of cannabis users. Baseline prolactin and prolactin response to d-fenfluramine were associated with the extent of previous cannabis use, Conclusions: Endocrinological abnormalities of ecstasy users may be closely related to their coincident cannabis use. Cannabis use may be an important confound in endocrinological studies of ecstasy users and should be looked for more systematically in future studies.

引用

页码：766 / 769

页数：4

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