A crucial piece in the puzzle of the artemisinin resistance mechanism in Plasmodium falciparum

被引：6
|
作者：
Bozdech, Zbynek [1 ]
Ferreira, Pedro E. [1 ]
Mok, Sachel [1 ]
机构：
[1] Nanyang Technol Univ, Sch Biol Sci, Singapore 639798, Singapore
来源：
TRENDS IN PARASITOLOGY | 2015年 / 31卷 / 08期
关键词：
malaria; drug resistance; artemisinin; MALARIA PARASITES; SPREAD;
D O I：
10.1016/j.pt.2015.06.004
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The spread of resistance of malaria infections to artemisinin is a major concern for the future. The Plasmodium falciparum phosphatidylinositol-3-kinase (PfPI3K) may be a potential target of artemisinin and effector of resistance. This could be mediated by the Kelch13 protein, the molecular marker of resistance that modulates PfPI3K ubiquitination.
引用
收藏
页码：345 / 346
页数：2
相关论文
共 50 条
  • [31] Observing in real time the evolution of artemisinin resistance in Plasmodium falciparum
    Carol Hopkins Sibley
    BMC Medicine, 13
  • [32] THE SUBSTANDARD ARTEMISININ EPIDEMIC - ACCELERATING RESISTANCE IN PLASMODIUM FALCIPARUM MALARIA?
    Hassett, Matthew R.
    Roepe, Paul D.
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2019, 101 : 274 - 274
  • [33] Exploring the Contribution of Candidate Genes to Artemisinin Resistance in Plasmodium falciparum
    Imwong, Mallika
    Dondorp, Arjen M.
    Nosten, Francois
    Yi, Poravuth
    Mungthin, Mathirut
    Hanchana, Sarun
    Das, Debashish
    Phyo, Aung Phae
    Lwin, Khin Maung
    Pukrittayakamee, Sasithon
    Lee, Sue J.
    Saisung, Suwannee
    Koecharoen, Kitti
    Nguon, Chea
    Day, Nicholas P. J.
    Socheat, Duong
    White, Nicholas J.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (07) : 2886 - 2892
  • [34] On the Mechanism of Chloroquine Resistance in Plasmodium falciparum
    Chinappi, Mauro
    Via, Allegra
    Marcatili, Paolo
    Tramontano, Anna
    PLOS ONE, 2010, 5 (11):
  • [35] INCREASED GLUTATHIONE PRODUCTION CONTRIBUTES TO THE MECHANISM OF ARTEMISININ RESISTANCE IN KELCH13-MUTANT PLASMODIUM FALCIPARUM
    Creek, Darren J.
    De Paoli, Amanda
    Siddiqui, Ghizal
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2019, 101 : 80 - 80
  • [36] TARGETING THE CELL STRESS RESPONSE OF PLASMODIUM FALCIPARUM TO OVERCOME ARTEMISININ RESISTANCE
    Tilley, Leann
    Xie, Stanley C.
    Dogovski, Con
    Kenny, Shannon
    Bridgford, Jess
    Burgio, Gaetan
    Foote, Simon
    Fidock, David A.
    Mok, Sachel
    Bozdech, Zbynek
    Chotivanich, Kesinee
    Klonis, Nick
    Dondorp, Arjen M.
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2015, 93 (04): : 573 - 573
  • [37] Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance
    Dogovski, Con
    Xie, Stanley C.
    Burgio, Gaetan
    Bridgford, Jess
    Mok, Sachel
    McCaw, James M.
    Chotivanich, Kesinee
    Kenny, Shannon
    Gnaedig, Nina
    Straimer, Judith
    Bozdech, Zbynek
    Fidock, David A.
    Simpson, Julie A.
    Dondorp, Arjen M.
    Foote, Simon
    Klonis, Nectarios
    Tilley, Leann
    PLOS BIOLOGY, 2015, 13 (04)
  • [38] Prevalence of potential mediators of artemisinin resistance in African isolates of Plasmodium falciparum
    Owoloye, Afolabi
    Olufemi, Michael
    Idowu, Emmanuel T.
    Oyebola, Kolapo M.
    MALARIA JOURNAL, 2021, 20 (01)
  • [39] Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum
    O'Brien, Connor
    Henrich, Philipp P.
    Passi, Neha
    Fidock, David A.
    CURRENT OPINION IN INFECTIOUS DISEASES, 2011, 24 (06) : 570 - 577
  • [40] Functional analysis of Plasmodium falciparum subpopulations associated with artemisinin resistance in Cambodia
    Dwivedi, Ankit
    Reynes, Christelle
    Kuehn, Axel
    Roche, Daniel B.
    Khim, Nimol
    Hebrard, Maxim
    Milanesi, Sylvain
    Rivals, Eric
    Frutos, Roger
    Menard, Didier
    Ben Mamoun, Choukri
    Colinge, Jacques
    Cornillot, Emmanuel
    MALARIA JOURNAL, 2017, 16
12345