A crucial piece in the puzzle of the artemisinin resistance mechanism in Plasmodium falciparum

被引：6
|
作者：
Bozdech, Zbynek [1 ]
Ferreira, Pedro E. [1 ]
Mok, Sachel [1 ]
机构：
[1] Nanyang Technol Univ, Sch Biol Sci, Singapore 639798, Singapore
来源：
TRENDS IN PARASITOLOGY | 2015年 / 31卷 / 08期
关键词：
malaria; drug resistance; artemisinin; MALARIA PARASITES; SPREAD;
D O I：
10.1016/j.pt.2015.06.004
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The spread of resistance of malaria infections to artemisinin is a major concern for the future. The Plasmodium falciparum phosphatidylinositol-3-kinase (PfPI3K) may be a potential target of artemisinin and effector of resistance. This could be mediated by the Kelch13 protein, the molecular marker of resistance that modulates PfPI3K ubiquitination.
引用
收藏
页码：345 / 346
页数：2
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