SUVOREXANT Dual Orexin OX1/OX2 Receptor Antagonist Treatment of Sleep Disorders

被引：2
|
作者：
Radl, S. [1 ]
机构：
[1] Zentiva, Prague 10237, Czech Republic
来源：
DRUGS OF THE FUTURE | 2013年 / 38卷 / 01期
关键词：
Orexin receptor antagonist; Insomnia; Sleep apnea; Suvorexant; MK-4305; PHARMACOLOGY; DISCOVERY; AMINATION;
D O I：
10.1358/dof.2013.038.01.1906425
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Suvorexant is a novel, selective, orally active dual orexin OX1 and OX2 receptor antagonist under development by Merck & Co. Phase Ill clinical trials for the treatment of insomnia have been completed and phase I clinical trials for the treatment of sleep apnea are under way. The phase III results suggested that patients taking suvorexant fell asleep faster and slept longer than those on placebo.
引用
收藏
页码：27 / 36
页数：10
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