Studying the rigidity of red blood cells induced by Plasmodium falciparum infection

被引：9
|
作者：
Paul, Apurba [1 ]
Ramdani, Ghania [2 ]
Tatu, Utpal [3 ]
Langsley, Gordon [2 ]
Natarajan, Vasant [1 ]
机构：
[1] Indian Inst Sci, Dept Phys, Bangalore 560012, Karnataka, India
[2] Cochin Inst, CNRS UMR8104, Inserm U1016, F-75014 Paris, France
[3] Indian Inst Sci, Dept Biochem, Bangalore 560012, Karnataka, India
来源：
SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期
关键词：
PROTEIN-KINASE; ATP; ERYTHROCYTES; LINK;
D O I：
10.1038/s41598-019-42721-w
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We study the effect of different chemical moieties on the rigidity of red blood cells (RBCs) induced by Plasmodium falciparum infection, and the bystander effect previously found. The infected cells are obtained from a culture of parasite-infected RBCs grown in the laboratory. The rigidity of RBCs is measured by looking at the Brownian fluctuations of individual cells in an optical-tweezers trap. The results point towards increased intracellular cyclic adenosine monophosphate (cAMP) levels as being responsible for the increase in rigidity.
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页数：4
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