How to maintain the genome in nuclear space

被引：28

作者：

Mitrentsi, Ioanna ^{[1
,2
,3
,4
]}

Yilmaz, Duygu ^{[1
,2
,3
,4
]}

Soutoglou, Evi ^{[1
,2
,3
,4
,5
]}

机构：

[1] Inst Genet & Biol Mol & Celullaire, F-67404 Illkirch Graffenstaden, France

[2] Inst Natl Sante & Rech Med, U964, F-67404 Illkirch Graffenstaden, France

[3] Ctr Natl Rech Sci, UMR7104, F-67404 Illkirch Graffenstaden, France

[4] Univ Strasbourg, F-67081 Strasbourg, France

[5] Univ Sussex, Sussex Univ, Genome Damage & Stabil Ctr, Sch Life Sci, Brighton BN1 9RH, E Sussex, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2020年 / 64卷

关键词：

DOUBLE-STRAND BREAK; DNA-DAMAGE RESPONSE; PHASE-SEPARATION; TRANSCRIPTIONAL REPRESSION; END RESECTION; REPAIR; RECOMBINATION; HETEROCHROMATIN; COMPARTMENTALIZATION; PHOSPHORYLATION;

D O I：

10.1016/j.ceb.2020.02.014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Genomic instability can be life-threatening. The fine balance between error-free and mutagenic DNA repair pathways is essential for maintaining genome integrity. Recent advances in DNA double-strand break induction and detection techniques have allowed the investigation of DNA damage and repair in the context of the highly complex nuclear structure. These studies have revealed that the 3D genome folding, nuclear compartmentalization and cytoskeletal components control the spatial distribution of DNA lesions within the nuclear space and dictate their mode of repair.

引用

页码：58 / 66

页数：9

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