Enantioselective Synthesis of Quaternary Carbon Stereogenic Centers through Copper-Catalyzed Conjugate Additions of Aryl- and Alkylaluminum Reagents to Acyclic Trisubstituted Enones

被引：55
|
作者：
Dabrowski, Jennifer A. [1 ]
Villaume, Matthew T. [1 ]
Hoveyda, Amir H. [1 ]
机构：
[1] Boston Coll, Dept Chem, Merkert Chem Ctr, Chestnut Hill, MA 02467 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 31期
关键词：
copper; enantioselective conjugate additions; N-heterocyclic carbenes; organoaluminums; quaternary carbons; SUBSTITUTED CYCLIC ENONES; N-HETEROCYCLIC CARBENE; GRIGNARD-REAGENTS; ASYMMETRIC 1,4-ADDITION; ALLYLIC SUBSTITUTIONS; DIALKYLZINC REAGENTS; ALUMINUM REAGENTS; CHIRAL CENTERS; CONSTRUCTION; STEREOCENTERS;
D O I：
10.1002/anie.201304035
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Acyclic quaternary carbons by conjugate addition: The first examples of catalytic enantioselective conjugate additions of aryl and alkyl units that generate acyclic all-carbon quaternary stereogenic centers have been developed (see scheme). The requisite organoaluminum reagents can either be prepared in situ from easily available organolithiums or purchased at low cost. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：8156 / 8159
页数：4
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