Enantioselective Synthesis of Quaternary Carbon Stereogenic Centers through Copper-Catalyzed Conjugate Additions of Aryl- and Alkylaluminum Reagents to Acyclic Trisubstituted Enones

被引：55

作者：

Dabrowski, Jennifer A. ^{[1
]}

Villaume, Matthew T. ^{[1
]}

Hoveyda, Amir H. ^{[1
]}

机构：

[1] Boston Coll, Dept Chem, Merkert Chem Ctr, Chestnut Hill, MA 02467 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 31期

关键词：

copper; enantioselective conjugate additions; N-heterocyclic carbenes; organoaluminums; quaternary carbons; SUBSTITUTED CYCLIC ENONES; N-HETEROCYCLIC CARBENE; GRIGNARD-REAGENTS; ASYMMETRIC 1,4-ADDITION; ALLYLIC SUBSTITUTIONS; DIALKYLZINC REAGENTS; ALUMINUM REAGENTS; CHIRAL CENTERS; CONSTRUCTION; STEREOCENTERS;

D O I：

10.1002/anie.201304035

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acyclic quaternary carbons by conjugate addition: The first examples of catalytic enantioselective conjugate additions of aryl and alkyl units that generate acyclic all-carbon quaternary stereogenic centers have been developed (see scheme). The requisite organoaluminum reagents can either be prepared in situ from easily available organolithiums or purchased at low cost. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8156 / 8159

页数：4

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