Regulation of B-cell function by NF-kappaB c-Rel in health and disease

被引：15
|
作者：
Basavarajappa, Shrikanth C. [1 ]
Ramakrishnan, Parameswaran [1 ,2 ,3 ]
机构：
[1] Case Western Reserve Univ, Univ Hosp Cleveland, Med Ctr, Dept Pathol,Sch Med, 6526,Wolstein Res Bldg,2103 Cornell Rd, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Sch Med, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2020年 / 77卷 / 17期
关键词：
B lymphocytes; Transcription; Antibody production; Lymphoma; Autoimmunity; GERMINAL CENTER B; TRANSCRIPTION FACTORS; MICE LACKING; MALIGNANT TRANSFORMATION; LYMPHOCYTE-PROLIFERATION; TRANSACTIVATION DOMAIN; NUCLEAR ACCUMULATION; CYCLE PROGRESSION; GENE-EXPRESSION; DNA-BINDING;
D O I：
10.1007/s00018-020-03488-w
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
B cells mediate humoral immune response and contribute to the regulation of cellular immune response. Members of the Nuclear Factor kappaB (NF-kappa B) family of transcription factors play a major role in regulating B-cell functions. NF-kappa B subunit c-Rel is predominantly expressed in lymphocytes, and in B cells, it is required for survival, proliferation, and antibody production. Dysregulation of c-Rel expression and activation alters B-cell homeostasis and is associated with B-cell lymphomas and autoimmune pathologies. Based on its essential roles, c-Rel may serve as a potential prognostic and therapeutic target. This review summarizes the current understanding of the multifaceted role of c-Rel in B cells and B-cell diseases.
引用
收藏
页码：3325 / 3340
页数：16
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