Skipping Cancer: Small Molecule Inhibitors of SKP2-Mediated p27 Degradation

被引：12
|
作者：
Rico-Bautista, Elizabeth [1 ]
Wolf, Dieter A. [1 ]
机构：
[1] Sanford Burnham Med Res Inst, Signal Transduct Program, La Jolla, CA 92037 USA
来源：
CHEMISTRY & BIOLOGY | 2012年 / 19卷 / 12期
关键词：
UBIQUITIN LIGASE; ACTIVATION; REVEALS; ENZYME;
D O I：
10.1016/j.chembiol.2012.12.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cullin-RING ubiquitin ligase, CRL1(SKP2), directing the degradation of the tumor suppressor p27, is a well validated drug target in a wide variety of human cancers. In this issue of Chemistry & Biology, Wu and colleagues describe first-in-class small molecule inhibitors of CRL1(SKP2)-mediated degradation of p27.
引用
收藏
页码：1497 / 1498
页数：2
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