Synthesis of graphene quantum dots and their applications in drug delivery

被引：201

作者：

Zhao, Changhong ^{[1
,2
]}

Song, Xuebin ^{[1
]}

Liu, Ya ^{[2
]}

Fu, Yifeng ^{[2
]}

Ye, Lilei ^{[3
]}

Wang, Nan ^{[3
]}

Wang, Fan ^{[1
]}

Li, Lu ^{[1
]}

Mohammadniaei, Mohsen ^{[4
]}

Zhang, Ming ^{[4
]}

Zhang, Qiqing ^{[1
]}

Liu, Johan ^{[2
,5
]}

机构：

[1] Xinxiang Med Univ, Sch Life Sci & Technol, Xinxiang 453003, Henan, Peoples R China

[2] Chalmers Univ Technol, Dept Microtechnol & Nanosci, Elect Mat & Syst Lab, S-41296 Gothenburg, Sweden

[3] SHT Smart High Tech AB, S-41133 Gothenburg, Sweden

[4] Tech Univ Denmark, Dept Hlth Technol, DK-2800 Lyngby, Denmark

[5] Shanghai Univ, Sch Automat & Mech Engn, SMIT Ctr, 20 Chengzhong Rd,Box 808, Shanghai 201800, Peoples R China

来源：

JOURNAL OF NANOBIOTECHNOLOGY | 2020年 / 18卷 / 01期

基金：

美国国家科学基金会; 中国国家自然科学基金;

关键词：

Graphene quantum dots; Top-down; Bottom-up; Drug delivery; Delivery-release mode; ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; IN-SITU SYNTHESIS; FACILE SYNTHESIS; CARBON NANOTUBES; UP-CONVERSION; PHYSICOCHEMICAL PROPERTIES; SUSTAINABLE SYNTHESIS; HYDROTHERMAL ROUTE; SENSING PROPERTIES;

D O I：

10.1186/s12951-020-00698-z

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This review focuses on the recent advances in the synthesis of graphene quantum dots (GQDs) and their applications in drug delivery. To give a brief understanding about the preparation of GQDs, recent advances in methods of GQDs synthesis are first presented. Afterwards, various drug delivery-release modes of GQDs-based drug delivery systems such as EPR-pH delivery-release mode, ligand-pH delivery-release mode, EPR-Photothermal delivery-Release mode, and Core/Shell-photothermal/magnetic thermal delivery-release mode are reviewed. Finally, the current challenges and the prospective application of GQDs in drug delivery are discussed.

引用

页数：32

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