DOUBLECORTIN-LIKE KINASE 1 (DCLK1) IS A MARKER OF SPECIFIC SUBPOPULATIONS OF CANCER STEM CELLS (CSCS) IN HUMAN CHOLANGIOCARCINOMA (CCA) AND ITS INHIBITION EXERTS ANTI-CANCER EFFECTS

被引:0
|
作者
Nevi, L. [1 ]
Di Matteo, S. [1 ]
Carpino, G. [2 ]
Cardinale, V. [1 ]
Ambrosino, V. [1 ]
Costantini, D. [1 ]
Safarikia, S. [1 ]
Manzi, E. [3 ]
De Rosa, A. M. [4 ]
Melandro, F. [1 ]
Bragazzi, M. C. [1 ]
Grazi, G. [3 ]
Berloco, P. B. [1 ]
Giuliante, F. [3 ]
Gaudio, E. [1 ]
Alvaro, D. [1 ]
机构
[1] Sapienza Univ Rome, Rome, Italy
[2] Univ Rome Foro Italico, Rome, Italy
[3] Regina Elena Inst Canc Res, Rome, Italy
[4] Univ Cattolica Sacro Cuore, Sch Med, Rome, Italy
关键词
D O I
10.1016/S1590-8658(18)30309-8
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
OC.08.1
引用
收藏
页码:E86 / E87
页数:2
相关论文
共 36 条
  • [21] Doublecortin-Like Kinase 1 (DCLK1) Regulates B Cell-Specific Moloney Murine Leukemia Virus Insertion Site 1 (Bmi-1) and is Associated with Metastasis and Prognosis in Pancreatic Cancer
    Li, Jian
    Wang, Yunchao
    Ge, Jiayun
    Li, Wenhua
    Yin, Liangyu
    Zhao, Zhiping
    Liu, Songsong
    Qin, Huan
    Yang, Jiali
    Wang, Lijiang
    Ni, Bing
    Liu, Yongkang
    Wang, Huaizhi
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 51 (01) : 262 - 277
  • [22] Role of cancer stem-cell marker doublecortin-like kinase 1 in head and neck squamous cell carcinoma
    Kadletz, Lorenz
    Thurnher, Dietmar
    Wiebringhaus, Robert
    Erovic, Boban M.
    Kotowski, Ulana
    Schneider, Sven
    Schmid, Rainer
    Kenner, Lukas
    Heiduschka, Gregor
    ORAL ONCOLOGY, 2017, 67 : 109 - 118
  • [23] Identification of small molecule inhibitors against doublecortin-like kinase 1 for targeting colon cancer stem cells
    Mary, L. Lizha
    Gor, Ravi
    Anand, T.
    Sivaramakrishnan, V
    Satish, R.
    INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 2024, 61 (09): : 552 - 562
  • [24] Doublecortin-like kinase 1 marks cancer stem-like cells and modulates drug-resistance, self-renewal, and tumorigenesis in renal cancer
    Ge, Yang
    Weygant, Nathaniel
    Qu, Dongfeng
    May, Randal
    Berry, William L.
    Chandrakesan, Parthasarathy
    Tomasek, James J.
    An, Guangyu
    Houchen, Courtney W.
    CANCER RESEARCH, 2016, 76
  • [25] Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells
    Kawamura, Daichi
    Takemoto, Yoshihiro
    Nishimoto, Arata
    Ueno, Koji
    Hosoyama, Tohru
    Shirasawa, Bungo
    Tanaka, Toshiki
    Kugimiya, Naruji
    Harada, Eijiro
    Hamano, Kimikazu
    ONCOLOGY REPORTS, 2017, 38 (05) : 3238 - 3244
  • [26] Small-Molecule Parkinson's Disease Kinase Inhibitor LRRK2-in-1 Demonstrates Potent Anti-Cancer Activity Through Inhibition of DCLK1
    Weygant, Nathaniel
    Qu, Dongfeng
    Berry, William L.
    May, Randal
    Chandrakesan, Parthasarathy
    Owen, Daniel
    Ali, Naushad
    Janknecht, Ralf
    Sureban, Sripathi M.
    Houchen, Courtney W.
    GASTROENTEROLOGY, 2014, 146 (05) : S694 - S694
  • [27] A 15-miRNA-Surrogate Signature for Doublecortin-Like Kinase 1 Tumor Stem Cell Marker Activity Predicts Survival in Colon, Pancreatic, and Stomach Cancer
    Weygant, Nathaniel
    Ge, Yang
    Qu, Dongfeng
    May, Randal
    Chandrakesan, Parthasarathy
    Bannerman-Menson, Edwin
    Vega, Kenneth J.
    Bronze, Michael S.
    An, Guangyu
    Houchen, Courtney W.
    GASTROENTEROLOGY, 2016, 150 (04) : S607 - S608
  • [28] Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem-like Cells Marked by DCLK1 Kinase
    Weygant, Nathaniel
    Ge, Yang
    Qu, Dongfeng
    Kaddis, John S.
    Berry, William L.
    May, Randal
    Chandrakesan, Parthasarathy
    Bannerman-Menson, Edwin
    Vega, Kenneth J.
    Tomasek, James J.
    Bronze, Michael S.
    An, Guangyu
    Houchen, Courtney W.
    CANCER RESEARCH, 2016, 76 (14) : 4090 - 4099
  • [29] Short (S) Isoform of Cancer-Stem-Cell Marker, DCLK1, Is Critically Required for Maintaining Proliferative/Tumorigenic Potential of Human Colon Cancer Cells (hCCCs) Independent of DCLK1-L Isoform
    O'Connell, Malaney R.
    Sarkar, Shubhashish
    Ward, Denise
    Singh, Pomila
    GASTROENTEROLOGY, 2016, 150 (04) : S605 - S605
  • [30] Overexpression of Mitochondrial GTPase MFN2 Represents a Negative Prognostic Marker in Human Gastric Cancer and Its Inhibition Exerts Anti-Cancer Effects
    Fang, Chia-Lang
    Sun, Ding-Ping
    Chen, Han-Kun
    Lin, Chih-Chan
    Hung, Shih-Ting
    Uen, Yih-Huei
    Lin, Kai-Yuan
    JOURNAL OF CANCER, 2017, 8 (07): : 1153 - 1161