机构:
Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Clin Outcomes Res Off, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Clin Outcomes Res Off, St Louis, MO 63110 USA
Megwalu, UC
[1
]
Finnell, JE
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Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Clin Outcomes Res Off, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Clin Outcomes Res Off, St Louis, MO 63110 USA
Finnell, JE
[1
]
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机构:
Piccirillo, JF
[1
]
机构:
[1] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, Clin Outcomes Res Off, St Louis, MO 63110 USA
GOAL: To determine if melatonin improves tinnitus and if this improvement is related to improvement in sleep. STUDY DESIGN AND SETTING: Prospective open-label Study of 24 patients with tinnitus. The patients took 3 mg of melatonin per day for 4 weeks, followed by 4 weeks of observation. The Tinnitus Handicap Inventory (THI) and the Pittsburgh Sleep Quality Index (PSQI) were administered. RESULTS: The mean THI score decreased significantly between weeks 0 and 4, and between weeks 0 and 8. The mean PSQI significantly decreased between weeks 0 and 4 (P < 0.0001), and between weeks 0 and 8 (P = 0.0003). The change in PSQI was significantly associated with the change in THI between weeks 0 and 4. The change in PSQI was not significantly associated with the change in THI between weeks 0 and 8. The change in the PSQI in the first 4 weeks was associated with the initial PSQI. There was no association between the initial THI and the change in the THI in the first 4 weeks. CONCLUSION: Melatonin use is associated with improvement of tinnitus and sleep. There was an association between the amount of improvement in sleep and tinnitus. The impact of melatonin on sleep was greatest among patients with the worst sleep quality, but its impact on tinnitus was not associated with the severity of the tinnitus. SIGNIFICANCE: Melatonin may be a safe treatment for patients with idiopathic tinnitus, especially those with sleep disturbance clue to tinnitus.
机构:
Gen Dr Aviator Victor Anastasiu Natl Inst Aeronau, 88th Mircea Vulcanescu Str, Bucharest 010825, Romania
Carol Davila Univ, Cent Emergency Mil Hosp, 88th Mircea Vulcanescu Str, Bucharest 010825, Romania
Carol Davila Univ, Med & Pharm Fac, 8 Eroii Sanit Str, Bucharest 050474, RomaniaGen Dr Aviator Victor Anastasiu Natl Inst Aeronau, 88th Mircea Vulcanescu Str, Bucharest 010825, Romania
Stefanescu, Dragos Cristian
Hainarosie, Razvan
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机构:
Carol Davila Univ, Med & Pharm Fac, 8 Eroii Sanit Str, Bucharest 050474, Romania
Inst Phonoaudiol & Funct ENT Surg Prof Dr Dorin H, 21th Mihail Cioranu Str, Bucharest 050751, RomaniaGen Dr Aviator Victor Anastasiu Natl Inst Aeronau, 88th Mircea Vulcanescu Str, Bucharest 010825, Romania
Hainarosie, Razvan
Zainea, Viorel
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机构:
Carol Davila Univ, Med & Pharm Fac, 8 Eroii Sanit Str, Bucharest 050474, Romania
Inst Phonoaudiol & Funct ENT Surg Prof Dr Dorin H, 21th Mihail Cioranu Str, Bucharest 050751, RomaniaGen Dr Aviator Victor Anastasiu Natl Inst Aeronau, 88th Mircea Vulcanescu Str, Bucharest 010825, Romania
Zainea, Viorel
Jecan, Radu Cristian
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机构:
Carol Davila Univ, Med & Pharm Fac, 8 Eroii Sanit Str, Bucharest 050474, Romania
Agripa Ionescu Emergency Clin Hosp Bucharest, 7 Ion Mincu Str, Bucharest 011356, RomaniaGen Dr Aviator Victor Anastasiu Natl Inst Aeronau, 88th Mircea Vulcanescu Str, Bucharest 010825, Romania
机构:
MGH Harvard Med Sch, Neurol, Boston, MA USA
Brigham & Womens Hosp, Div Sleep & Circadian Disorders, Med, 75 Francis St, Boston, MA 02115 USAMGH Harvard Med Sch, Neurol, Boston, MA USA
Klerman, E. B.
St Hilaire, M. A.
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机构:
Brigham & Womens Hosp, Div Sleep & Circadian Disorders, Med, 75 Francis St, Boston, MA 02115 USAMGH Harvard Med Sch, Neurol, Boston, MA USA
St Hilaire, M. A.
Hilditch, C. J.
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机构:
NASA, Ames Res Ctr, San Jose State Univ Res Fdn, Fatigue Countermeasures Lab, Moffett Field, CA USAMGH Harvard Med Sch, Neurol, Boston, MA USA
Hilditch, C. J.
Rahman, S. A.
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机构:
Brigham & Womens Hosp, Div Sleep & Circadian Disorders, Med, 75 Francis St, Boston, MA 02115 USAMGH Harvard Med Sch, Neurol, Boston, MA USA
机构:Tel Aviv Univ, George S Wise Fac Life Sci, Dept Neurobiochem, IL-69978 Tel Aviv, Israel
Gorfine, Tali
Assaf, Yaniv
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机构:Tel Aviv Univ, George S Wise Fac Life Sci, Dept Neurobiochem, IL-69978 Tel Aviv, Israel
Assaf, Yaniv
Goshen-Gottstein, Yonatan
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机构:Tel Aviv Univ, George S Wise Fac Life Sci, Dept Neurobiochem, IL-69978 Tel Aviv, Israel
Goshen-Gottstein, Yonatan
Yeshurun, Yaara
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机构:Tel Aviv Univ, George S Wise Fac Life Sci, Dept Neurobiochem, IL-69978 Tel Aviv, Israel
Yeshurun, Yaara
Zisapel, Nava
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机构:
Tel Aviv Univ, George S Wise Fac Life Sci, Dept Neurobiochem, IL-69978 Tel Aviv, IsraelTel Aviv Univ, George S Wise Fac Life Sci, Dept Neurobiochem, IL-69978 Tel Aviv, Israel
机构:
Univ Autonoma Madrid, Dept Psychiat, Human Sleep & Appl Chronobiol Lab, C Arzobispo Morcillo, Madrid 428029, SpainUniv Autonoma Madrid, Dept Psychiat, Human Sleep & Appl Chronobiol Lab, C Arzobispo Morcillo, Madrid 428029, Spain
Vela-Bueno, Antonio
Olavarrieta-Bernardino, Sara
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机构:
Univ Autonoma Madrid, Dept Psychiat, Human Sleep & Appl Chronobiol Lab, C Arzobispo Morcillo, Madrid 428029, SpainUniv Autonoma Madrid, Dept Psychiat, Human Sleep & Appl Chronobiol Lab, C Arzobispo Morcillo, Madrid 428029, Spain
Olavarrieta-Bernardino, Sara
Fernandez-Mendoza, Julio
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机构:
Univ Autonoma Madrid, Dept Psychiat, Human Sleep & Appl Chronobiol Lab, C Arzobispo Morcillo, Madrid 428029, SpainUniv Autonoma Madrid, Dept Psychiat, Human Sleep & Appl Chronobiol Lab, C Arzobispo Morcillo, Madrid 428029, Spain
Fernandez-Mendoza, Julio
Aguirre-Berrocal, Acacia
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机构:
Circadian Technologies Inc, Stoneham, MA 02180 USAUniv Autonoma Madrid, Dept Psychiat, Human Sleep & Appl Chronobiol Lab, C Arzobispo Morcillo, Madrid 428029, Spain