Plasmonic Resonance Energy Transfer Enhanced Photodynamic Therapy with Au@SiO2@Cu2O/Perfluorohexane Nanocomposites

被引：74
|
作者：
Liu, Conghui [1 ]
Dong, Haifeng [1 ]
Wu, Nianqiang [2 ]
Cao, Yu [1 ]
Zhang, Xueji [1 ]
机构：
[1] Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Res Ctr Bioengn & Sensing Technol, Beijing 100083, Peoples R China
[2] West Virginia Univ, Dept Mech & Aerosp Engn, Morgantown, WV 26506 USA
来源：
ACS APPLIED MATERIALS & INTERFACES | 2018年 / 10卷 / 08期
基金：
中国国家自然科学基金;
关键词：
photodynamic therapy; plasmonic resonance energy transfer; core-shell structure; self-enriched oxygen; peifluorocarbon; NEAR-INFRARED LIGHT; OXYGEN CARRIERS; QUANTUM DOTS; NANOPARTICLES; METAL; GOLD; EFFICIENT; HYPOXIA; NANOSTRUCTURES;
D O I：
10.1021/acsami.8b00112
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Reactive oxygen species generation efficiency of photosensitizers and hypoxia microenvironment in solid tumor hamper photodynamic therapy (PDT) efficacy. Here, we introduce an efficient inorganic photosensitizer by incorporating plasmonic gold metal nanostructures into Cu2O semiconductors for PDT. By utilizing the plasmon-induced resonance energy transfer (PIRET) process from Au to Cu2O, Au@SiO2@Cu2O (ASC) demonstrates a high singlet oxygen quantum yield of 0.71 under a 670 nm laser irradiation. The ASC is loaded into oxygen self-enriched perfluorohexane (PFH) droplets and coated with liposome (Lip) to form Lip(ASC/PFH) nanocomposites. The achieved Lip(ASC/PFH) shows considerable anticancer efficacy for in vitro cancer cells and in vivo tumor growth. The proposed oxygen self-enriched PIRET-PDT concept has significant implication in PDT design.
引用
收藏
页码：6991 / 7002
页数：12
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