Catalyst- and solvent-free approach to 2-arylated quinolines via [5+1] annulation of 2-methylquinolines with diynones

被引：6

作者：

Zhao, Hai-Yuan ^{[1
,2
]}

Wu, Fu-Song ^{[2
]}

Yang, Li ^{[3
]}

Liang, Ying ^{[1
]}

Cao, Xiao-Lin ^{[2
]}

Wang, Heng-Shan ^{[2
]}

Pan, Ying-Ming ^{[2
]}

机构：

[1] Guilin Univ Elect Technol, Sch Life & Environm Sci, Guilin 541004, Peoples R China

[2] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China

[3] Guangxi Zhuang Autonomous Reg Forestry Res Inst, Guangxi Key Lab Special Nonwood Forest Cultivat &, Nanning 530002, Peoples R China

来源：

RSC ADVANCES | 2018年 / 8卷 / 09期

基金：

中国国家自然科学基金;

关键词：

CROSS-COUPLING REACTIONS; GAMMA-AMINO-ALCOHOLS; CYCLOOXYGENASE-2; INHIBITORS; BIOLOGICAL EVALUATION; ASYMMETRIC CATALYSIS; SECONDARY ALCOHOLS; PINCER COMPLEXES; DIRECT ARYLATION; BOND ACTIVATION; ARYL HALIDES;

D O I：

10.1039/c7ra12716b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel route for the synthesis of 2-arylated quinolines through a [5 + 1] annulation directly from 2-methylquinolines and diynones under catalyst-free and solvent-free conditions was disclosed. This synthetic process was atom-economic, with good tolerance of a broad range of functional groups, and with great practical worth.

引用

页码：4584 / 4587

页数：4

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