Construction of benzothiophene fused pyrrolidone in water via a catalyst-free process and a mechanism study

被引：17
|
作者：
Shen, Jinhui [1 ]
Yu, Aimin [1 ]
Zhang, Lei [2 ,3 ]
Meng, Xiangtai [1 ]
机构：
[1] Tianjin Univ Technol, Sch Chem & Chem Engn, Tianjin Key Lab Drug Targeting & Bioimaging, Tianjin Key Lab Organ Solar Cells & Photochem Con, Tianjin 300384, Peoples R China
[2] Tianjin Chengjian Univ, Sch Sci, Tianjin Engn Technol Ctr Chem Wastewater Source R, Tianjin 300384, Peoples R China
[3] Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China
来源：
GREEN CHEMISTRY | 2020年 / 22卷 / 20期
基金：
中国国家自然科学基金;
关键词：
2,3-DISUBSTITUTED BENZOTHIOPHENES; 2-ALKYNYLTHIOANISOLES; DERIVATIVES; ANNULATION; INHIBITORS; SULFIDES; ANALOGS; IODINE;
D O I：
10.1039/d0gc01860k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel three-component domino reaction towards benzothiophene fused pyrrolidone derivatives was developed in an environmentally benign manner. The reaction proceeded well in aqueous media, and delivered the desired products in high yields with excellent selectivity. Density functional calculations located a multi-step reaction pathway and identified the intramolecular nucleophilic addition step to be the rate-determining step.
引用
收藏
页码：6798 / 6803
页数：6
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