Cytokines that regulate autoimmunity

被引：75
|
作者：
Diveu, Caroline [1 ]
McGeachy, Mandy J. [1 ]
Cua, Daniel J. [1 ]
机构：
[1] Schering Plough Biopharma, Discovery Res, Palo Alto, CA 94304 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2008年 / 20卷 / 06期
关键词：
D O I：
10.1016/j.coi.2008.09.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent advances have revealed new insights in cytokine regulation of inflammatory responses. TGF beta acting together with pro-inflammatory cytokines such as IL-6 promotes lineage commitment of ROR gamma-dependent Th17 cells. IL-23 - a member of the IL-12 family - activates the effector function of Th17 cells to promote skin, lung, and mucosal immunity. However, when cysregulated, these cells are important players in autoimmune inflammation. Unexpectedly, IL-27 - another IL-12 family member - plays an opposing role by inducing IL-10 production as well as downregulating both Th17 and Th1-mediated immune pathologies.
引用
收藏
页码：663 / 668
页数：6
相关论文
共 50 条
  • [41] CYTOKINES REGULATE GENES INVOLVED IN ATHEROGENESIS
    LIBBY, P
    GALIS, ZS
    ATHEROSCLEROSIS III: RECENT ADVANCES IN ATHEROSCLEROSIS RESEARCH: THE THIRD SARATOGA INTERNATIONAL CONFERENCE ON ATHEROSCLEROSIS IN NEKOMA, 1995, 748 : 158 - 170
  • [42] Defining critical cytokines that mediate DC induced autoimmunity
    Ohashi, Pamela S.
    Lin, Albert
    Dissanayake, Dilan
    CYTOKINE, 2010, 52 (1-2) : 44 - 44
  • [43] POSSIBLE ROLE OF CYTOKINES IN THE PATHOGENESIS OF NONORGAN SPECIFIC AUTOIMMUNITY
    ZUPO, S
    DONO, M
    AZZONI, L
    CHIORAZZI, N
    FERRARINI, M
    INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, 1992, 5 (02) : 149 - 154
  • [44] Targeting cytokines of the interleukin-12 family in autoimmunity
    Kang, BY
    Kim, TS
    CURRENT MEDICINAL CHEMISTRY, 2006, 13 (10) : 1149 - 1156
  • [45] Proinflammatory cytokines and autoimmunity in Churg-Strauss syndrome
    Hellmich, B
    Csernok, E
    Gross, WL
    AUTOIMMUNE DISEASES AND TREATMENT: ORGAN-SPECIFIC AND SYSTEMIC DISORDERS, 2005, 1051 : 121 - 131
  • [46] Autoantibodies to Chemokines and Cytokines Participate in the Regulation of Cancer and Autoimmunity
    Karin, Nathan
    FRONTIERS IN IMMUNOLOGY, 2018, 9
  • [47] The Role of Cytokines in T-Cell Tolerance and Autoimmunity
    Abbas, Abul K.
    CYTOKINE, 2011, 56 (01) : 103 - 103
  • [48] IL-36 cytokines in autoimmunity and inflammatory disease
    Ding, Liping
    Wang, Xiaohui
    Hong, Xiaoping
    Lu, Liwei
    Liu, Dongzhou
    ONCOTARGET, 2018, 9 (02) : 2895 - 2901
  • [49] Targeting cytokines in autoimmunity: new approaches, new promise
    Andreakos, E
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2003, 3 (03) : 435 - 447
  • [50] Targeting metabolism to regulate immune responses in autoimmunity and cancer
    Patel, Chirag H.
    Leone, Robert D.
    Horton, Maureen R.
    Powell, Jonathan D.
    NATURE REVIEWS DRUG DISCOVERY, 2019, 18 (09) : 669 - 688
12345