Cytokines that regulate autoimmunity

被引：75
|
作者：
Diveu, Caroline [1 ]
McGeachy, Mandy J. [1 ]
Cua, Daniel J. [1 ]
机构：
[1] Schering Plough Biopharma, Discovery Res, Palo Alto, CA 94304 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2008年 / 20卷 / 06期
关键词：
D O I：
10.1016/j.coi.2008.09.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent advances have revealed new insights in cytokine regulation of inflammatory responses. TGF beta acting together with pro-inflammatory cytokines such as IL-6 promotes lineage commitment of ROR gamma-dependent Th17 cells. IL-23 - a member of the IL-12 family - activates the effector function of Th17 cells to promote skin, lung, and mucosal immunity. However, when cysregulated, these cells are important players in autoimmune inflammation. Unexpectedly, IL-27 - another IL-12 family member - plays an opposing role by inducing IL-10 production as well as downregulating both Th17 and Th1-mediated immune pathologies.
引用
收藏
页码：663 / 668
页数：6
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