New insights into the architecture of the islet of Langerhans: a focused cross-species assessment

被引：70
|
作者：
Arrojo e Drigo, Rafael [1 ]
Ali, Yusuf [1 ]
Diez, Juan [1 ]
Srinivasan, Dinesh Kumar [1 ]
Berggren, Per-Olof [1 ,2 ,3 ]
Boehm, Bernhard O. [1 ,2 ,4 ]
机构：
[1] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 637553, Singapore
[2] Univ London Imperial Coll Sci Technol & Med, London, England
[3] Karolinska Inst, Karolinska Univ Hosp L1, Rolf Luft Res Ctr Diabet & Endocrinol, SE-17176 Stockholm, Sweden
[4] Univ Ulm, Med Ctr, Dept Internal Med 1, D-89069 Ulm, Germany
来源：
DIABETOLOGIA | 2015年 / 58卷 / 10期
关键词：
Cross-species assessment; Intra-islet signalling; Islet cell architecture; Islets of Langerhans; Non-human primates; Review; BETA-CELL APOPTOSIS; POSITIVE AUTOCRINE SIGNAL; ENDOTHELIAL GROWTH-FACTOR; PANCREATIC-ISLETS; INSULIN-SECRETION; AMYLOID POLYPEPTIDE; GLUCAGON RECEPTORS; EUROPEAN SUBJECTS; ENDOCRINE-CELLS; BLOOD-VESSELS;
D O I：
10.1007/s00125-015-3699-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The human genome project and its search for factors underlying human diseases has fostered a major human research effort. Therefore, unsurprisingly, in recent years we have observed an increasing number of studies on human islet cells, including disease approaches focusing on type 1 and type 2 diabetes. Yet, the field of islet and diabetes research relies on the legacy of rodent-based investigations, which have proven difficult to translate to humans, particularly in type 1 diabetes. Whole islet physiology and pathology may differ between rodents and humans, and thus a comprehensive cross-species as well as species-specific view on islet research is much needed. In this review we summarise the current knowledge of interspecies islet cytoarchitecture, and discuss its potential impact on islet function and future perspectives in islet pathophysiology research.
引用
收藏
页码：2218 / 2228
页数：11
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