Solid phase synthesis of hydantoin library using a novel cyclization and traceless cleavage step

被引：80
|
作者：
Kim, SW
Ahn, SY
Koh, JS
Lee, JH
Ro, S
Cho, HY
机构：
[1] Biotech Research Institute, LG Chemical Ltd., Research Park Science Town
来源：
TETRAHEDRON LETTERS | 1997年 / 38卷 / 26期
关键词：
D O I：
10.1016/S0040-4039(97)00986-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The variety of N,N-disubstituted hydantoin libraries were constructed using derivatives of amino acids, aromatic aldehydes, and isocyanates. The cyclization step of hydantoin was a novel, fast and clean reaction and completed within five minutes to 1 hour with near diisopropylamine. All library compounds were obtained in excellent yield with high purity even after 5 steps. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：4603 / 4606
页数：4
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