New efficient synthesis of trisubstituted imidazolidine-2-thiones and thiazoles via vinyliminophosphoranes

被引：33
|
作者：
Xie, Hai [1 ,2 ]
Liu, Jian-Chao [1 ]
Wu, Lei [1 ]
Ding, Ming-Wu [1 ]
机构：
[1] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China
[2] Shanxi Datong Univ, Coll Chem & Chem Engn, Datong 037009, Shanxi, Peoples R China
来源：
TETRAHEDRON | 2012年 / 68卷 / 38期
基金：
中国国家自然科学基金;
关键词：
BIOLOGICAL EVALUATION; UNEXPECTED SYNTHESIS; FACILE SYNTHESIS; INHIBITORS; IMIDAZOLES; DERIVATIVES; ENAZIDES; DESIGN; SERIES;
D O I：
10.1016/j.tet.2012.07.002
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Isothiocyanate 6, obtained from vinyliminophosphorane 4 with CS2, reacted with various aliphatic primary amines to afford directly the 1,4,5-trisubstituted imidazolidine-2-thiones 5. However, the reaction of isothiocyanate 6 with aliphatic secondary amines provided 2,4,5-trisubstituted thiazoles 10 in good yields. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7984 / 7990
页数：7
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