Endemic Pemphigus Foliaceus: Towards Understanding Autoimmune Mechanisms of Disease Development

被引：10

作者：

Di Zenzo, Giovanni ^{[1
]}

Zambruno, Giovanna ^{[1
]}

Borradori, Luca ^{[2
]}

机构：

[1] Ist Dermopat Immacolata IDI IRCCS, Lab Mol & Cell Biol, I-00167 Rome, Italy

[2] Univ Bern, Inselspital, Univ Hosp Bern, Dept Dermatol, CH-3010 Bern, Switzerland

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2012年 / 132卷 / 11期

关键词：

FOGO SELVAGEM; ANTI-DESMOGLEIN-1; ANTIBODIES; HEALTHY-SUBJECTS; AUTOANTIBODIES; PATHOGENESIS; ANTIGEN; EPITOPE; GENE;

D O I：

10.1038/jid.2012.369

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Fogo selvagem is an endemic form of pemphigus foliaceus (EPF) found in Brazil. Environmental and genetic factors are thought to contribute to the disease, which is associated with pathogenic IgG4 autoantibodies against the desmosomal cadherin desmoglein 1. In this issue, as an additional framework to understand autoimmune mechanisms in EPF, Flores et al. have investigated whether fogo selvagem patients and healthy individuals from endemic areas develop autoantibody responses against other desmosomal cadherins and E-cadherin.

引用

页码：2499 / 2502

页数：4

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