The origins and uses of mouse outbred stocks

被引:267
|
作者
Chia, R
Achilli, F
Festing, MFW
Fisher, EMC
机构
[1] Inst Neurol, Dept Neurodegenerat Dis, London WC1N 3BG, England
[2] Univ Leicester, MRC, Toxicol Unit, Leicester LE1 9HN, Leics, England
关键词
D O I
10.1038/ng1665
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Outbred mouse stocks, often used in genetics, toxicology and pharmacology research, have been generated in rather haphazard ways. Understanding the characteristics of these stocks and their advantages and disadvantages is important for experimental design. In many studies these mice are used inappropriately, wasting animals' lives and resources on suboptimal experiments. Recently, however, researchers from the field of complex trait analysis have capitalized on the genetics of outbred stocks to refine the identification of quantitative trait loci. Here we assess the most widely used outbred stocks of mice and present guidelines for their use.
引用
收藏
页码:1181 / 1186
页数:6
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