Aging and oxidative stress: studies of some genes involved both in aging and in response to oxidative stress

被引：71
|
作者：
Camougrand, N [1 ]
Rigoulet, M [1 ]
机构：
[1] CNRS, Inst Biochim & Genet Cellulaires, F-33077 Bordeaux, France
来源：
RESPIRATION PHYSIOLOGY | 2001年 / 128卷 / 03期
关键词：
ageing; theories; reactive oxygen species; mitochondria; theory of ageing; oxygen; reactive species;
D O I：
10.1016/S0034-5687(01)00314-0
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Aging is a complex physiological phenomenon and several theories have been developed about its origin. Among such theories, the 'mitochondrial theory of aging' has been supported by numerous studies and reviews. Cell oxidative damage, in particular the accumulation of mtDNA mutations, is determined by the rate of reactive oxygen species production and degradation induced by the antioxidant defense systems. In this review, data from our laboratory and from the recent literature have been examined to provide arguments that reinforce the crucial role of mitochondria in aging. Various genes that affect life span have been described in numerous organisms. Some of them encode signal transduction proteins and participate in the regulation of mitochondrial metabolism. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：393 / 401
页数：9
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