Role of TH17 cytokines in the control of colorectal cancer

被引：106
|
作者：
De Simone, Veronica [1 ]
Pallone, Francesco [1 ]
Monteleone, Giovanni [1 ]
Stolfi, Carmine [1 ]
机构：
[1] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 12期
关键词：
anti-cytokine therapy; colitis-associated colon cancer; IL-17A; IL-17F; IL-21; IL-22; inflammation; NF kappa B; STAT3; T(H)17 cells; ROR-GAMMA-T; COLON-CANCER; PROMOTES ANGIOGENESIS; TUMOR-GROWTH; TGF-BETA; CELLS; DIFFERENTIATION; COLITIS; IL-22; INTERLEUKIN-21;
D O I：
10.4161/onci.26617
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Immune/inflammatory cells infiltrate almost all human solid tumors and affect all stages of carcinogenesis as they produce different cytokine subsets. The overproduction of T(H)17 cytokines marks the early stages of colorectal carcinoma (CRC) and negatively influences the prognosis of CRC patients. Studies with murine models of CRC have delineated the mechanisms by which T(H)17 cytokines, notably, interleukin (IL)-17A, IL-17F, IL-21, and IL-22, regulate oncogenesis and tumor progression, paving the way to the development of novel anticancer drugs. In this review article, we discuss experimental data supporting the role of T(H)17 cytokines in the modulation of colorectal tumorigenesis.
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页数：6
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