Germ cell tumors of the CNS in children: recent advances in therapy

被引:36
|
作者
Diez, B
Balmaceda, C
Matsutani, M
Weiner, HL
机构
[1] Childrens Hosp Buenos Aires, RA-1425 Buenos Aires, DF, Argentina
[2] Columbia Presbyterian Med Ctr, Neurol Inst, New York, NY 10032 USA
[3] Saitama Med Sch, Dept Neurosurg, Moroyama, Saitama 35004, Japan
[4] NYU, Med Ctr, Div Pediat Neurosurg, New York, NY 10016 USA
关键词
brain neoplasm; chemotherapy; germ cell tumor; germinoma; radiation therapy;
D O I
10.1007/s003810050546
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Primary germ cell tumors of the central nervous system are rare neoplasms, accounting for no more than 2% of all malignancies in children and young people under 20 in the Western hemisphere. They have unique features related to age at diagnosis and sites of origin,as well as race and gender predilection. Prognosis has been clearly shown to be strongly related to pathological classification as either pure germinoma or nongerminomatous germ cell turner, although many of these lesions are comprised of mixed elements. The presence of serum or cerebrospinal fluid tumor marker elevation has been an essential determinant of response to treatment. Because of the deleterious effects of irradiation an the immature nervous system, investigators have used chemotherapeutic strategies that either reduce or eliminate radiation therapy. In this article, we review the most recent advances in therapy for CNS germ cell tumors in the pediatric population and highlight the importance of cooperative trials in this setting.
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页码:578 / 585
页数:8
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