Enantio- and Regioselective Conjugate Addition of Organometallic Reagents to Linear Polyconjugated Nitroolefins

被引：28
|
作者：
Tissot, Matthieu [1 ]
Alexakis, Alexandre [1 ]
机构：
[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2013年 / 19卷 / 34期
基金：
瑞士国家科学基金会; 新加坡国家研究基金会;
关键词：
asymmetric catalysis; conjugate addition; copper; ligand effects; phosphine ligands; ACCEPTOR-SUBSTITUTED ENYNES; DIALKYLZINC REAGENTS; 1,6-CONJUGATE ADDITION; MECHANISM; ALLENES; 1,4-ADDITION; NITROALKENES; DIETHYLZINC; ROUTE;
D O I：
10.1002/chem.201300538
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The copper-catalysed conjugate addition of trialkylaluminium and dialkylzinc reagents to polyconjugated nitroolefins (nitrodiene and nitroenyne derivatives) is reported. A reversed Josiphos ligand L7 allows for the selective 1,4- or 1,6-addition with high enantioselectivities.
引用
收藏
页码：11352 / 11363
页数：12
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