Superparamagnetic microrobots: fabrication by two-photon polymerization and biocompatibility

被引：107
|
作者：
Suter, Marcel [1 ]
Zhang, Li [2 ]
Siringil, Erdem C. [3 ]
Peters, Christian [1 ]
Luehmann, Tessa [4 ]
Ergeneman, Olgac [3 ]
Peyer, Kathrin E. [3 ]
Nelson, Bradley J. [3 ]
Hierold, Christofer [1 ]
机构：
[1] ETH, Zurich, Switzerland
[2] Chinese Univ Hong Kong, Dept Mech & Automat Engn, Shatin, Hong Kong, Peoples R China
[3] ETH, Inst Robot & Intelligent Syst, Zurich, Switzerland
[4] Univ Wurzburg, Inst Pharm & Food Chem, D-97070 Wurzburg, Germany
来源：
BIOMEDICAL MICRODEVICES | 2013年 / 15卷 / 06期
基金：
瑞士国家科学基金会;
关键词：
Superparamagnetic nanocomposite; Microrobots; Magnetic actuation; Cytotoxicity; NANOPARTICLES; NANOMACHINES; PROPULSION;
D O I：
10.1007/s10544-013-9791-7
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
This work presents the fabrication and controlled actuation of swimming microrobots made of a magnetic polymer composite (MPC) consisting of 11-nm-diameter magnetite (Fe3O4) nanoparticles and photocurable resin (SU-8). Two-photon polymerization (TPP) is used to fabricate the magnetic microstructures. The material properties and the cytotoxicity of the MPC with different nanoparticle concentrations are characterized. The live/dead staining tests indicate that MPC samples with varied concentrations, up to 10 vol.%, have negligible cytotoxicity after 24 h incubation. Fabrication parameters of MPC with up to 4 vol.% were investigated. We demonstrate that the helical microdevices made of 2 vol.% MPC were capable of performing corkscrew motion in water applying weak uniform rotating magnetic fields.
引用
收藏
页码：997 / 1003
页数：7
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