Superparamagnetic microrobots: fabrication by two-photon polymerization and biocompatibility

被引：107

作者：

Suter, Marcel ^{[1
]}

Zhang, Li ^{[2
]}

Siringil, Erdem C. ^{[3
]}

Peters, Christian ^{[1
]}

Luehmann, Tessa ^{[4
]}

Ergeneman, Olgac ^{[3
]}

Peyer, Kathrin E. ^{[3
]}

Nelson, Bradley J. ^{[3
]}

Hierold, Christofer ^{[1
]}

机构：

[1] ETH, Zurich, Switzerland

[2] Chinese Univ Hong Kong, Dept Mech & Automat Engn, Shatin, Hong Kong, Peoples R China

[3] ETH, Inst Robot & Intelligent Syst, Zurich, Switzerland

[4] Univ Wurzburg, Inst Pharm & Food Chem, D-97070 Wurzburg, Germany

来源：

BIOMEDICAL MICRODEVICES | 2013年 / 15卷 / 06期

基金：

瑞士国家科学基金会;

关键词：

Superparamagnetic nanocomposite; Microrobots; Magnetic actuation; Cytotoxicity; NANOPARTICLES; NANOMACHINES; PROPULSION;

D O I：

10.1007/s10544-013-9791-7

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This work presents the fabrication and controlled actuation of swimming microrobots made of a magnetic polymer composite (MPC) consisting of 11-nm-diameter magnetite (Fe3O4) nanoparticles and photocurable resin (SU-8). Two-photon polymerization (TPP) is used to fabricate the magnetic microstructures. The material properties and the cytotoxicity of the MPC with different nanoparticle concentrations are characterized. The live/dead staining tests indicate that MPC samples with varied concentrations, up to 10 vol.%, have negligible cytotoxicity after 24 h incubation. Fabrication parameters of MPC with up to 4 vol.% were investigated. We demonstrate that the helical microdevices made of 2 vol.% MPC were capable of performing corkscrew motion in water applying weak uniform rotating magnetic fields.

引用

页码：997 / 1003

页数：7

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