Oncolytic Virotherapy

被引：57

作者：

Sze, Daniel Y. ^{[1
]}

Reid, Tony R. ^{[3
]}

Rose, Steven C. ^{[2
]}

机构：

[1] Stanford Univ, Sch Med, Div Intervent Radiol, Stanford Canc Ctr, Stanford, CA 94305 USA

[2] Univ Calif San Diego, Div Intervent Radiol, San Diego, CA 92103 USA

[3] Univ Calif San Diego, Moores Canc Ctr, Div Med Oncol, La Jolla, CA 92093 USA

来源：

JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY | 2013年 / 24卷 / 08期

关键词：

PHASE-I TRIAL; CLINICAL-TRIAL; REPLICATION-COMPETENT; ADENOVIRUS ONYX-015; VIRUS NV1020; I/II TRIAL; CANCER; INJECTION; THERAPY; JX-594;

D O I：

10.1016/j.jvir.2013.05.040

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Oncolytic Virotherapy is an emerging technology that uses engineered viruses to treat malignancies. Viruses can be designed with biological specificity to infect Cancerous cells preferentially, and to replicate in these cells exclusively. Malignant cells may be killed directly by overwhelming viral infection and lysis, which releases additional viral particles, to infect neighboring cells and distant metastases. Viral infections may also activate the immune system,, unmask stealthy tumor antigens, and aid the immune system to recognize and attack neoplasms. Delivery of live virus particles is potentially complex, and may require the expertise of the interventional community.

引用

页码：1115 / 1122

页数：8

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